ERK2 drives tumour cell migration in 3D microenvironments by suppressing expression of Rab17 and Liprin-β2
نویسندگان
چکیده
منابع مشابه
ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.
Upregulation of the extracellular signal-regulated kinase (ERK) pathway has been shown to contribute to tumour invasion and progression. Because the two predominant ERK isoforms (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) are highly homologous and have indistinguishable kinase activities in vitro, both enzymes were believed to be redundant and interchangeable. To challenge this...
متن کاملERK2 drives tumour cell migration in three- dimensional microenvironments by suppressing expression of Rab17 and liprin-b2
Upregulation of the extracellular signal-regulated kinase (ERK) pathway has been shown to contribute to tumour invasion and progression. Because the two predominant ERK isoforms (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) are highly homologous and have indistinguishable kinase activities in vitro, both enzymes were believed to be redundant and interchangeable. To challenge this...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.092916